The Department of Translational Medicine and Physiology welcomes Dr. Frank C. Schroeder, Professor at Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University to WSU Spokane on Tuesday, Dec. 10. He will be providing his seminar at 12:10 p.m., “Host-microbe metabolic interactions in C. elegans and mouse,” in SAC 347 and via Zoom.
Metabolites derived from the intestinal microbiota extensively modulate animal physiology and in particular lipid metabolism; however, to what extent host responses balance the effects of microbiota-derived metabolites remains unclear. I will first discuss an example from C. elegans.
Similarly, untargeted metabolomics of mouse tissues revealed complementary host and microbial regulation of the farnesoid X receptor (FXR) via bile acid (BA) derivatives. Conjugation of microbiota-derived BAs with methylcysteamine (BA-MCYs) by the host pantetheinase, VNN1/vanin 1, inverts bile acid function in the hepatobiliary system. Whereas microbiota-derived free BAs function as FXR agonists, BA-MCYs act as potent FXR antagonists in vitro and accordingly regulate lipid metabolism in vivo.
For the full talk abstract, questions/Zoom link? Contact Michelle Sanchez at michelle.r.sanchez@wsu.edu.
