The Gene and Linda Voiland School of Chemical Engineering and Bioengineering Graduate Seminar Series:
Todd Hall 311 at 12:10 p.m., Monday, January 25
Andreas E. Vasdekis
Department of Physics, University of Idaho, Moscow, ID
Andreas received his PhD in soft-matter photophysics and applications at the University of St. Andrews (U.K.). Following a short spell at Caltech (U.S.), he spent three years as a postdoctoral scholar at the Ecole Polytechnique Federale de Lausanne (Switzerland). Prior to joining the University of Idaho in late 2014, he was at the Pacific Northwest National Laboratory (U.S.) for two years investigating metabolism at the single cell level. Presently, his group’s activities focus on single cell biophysics, including the development of enabling optofluidic, microfluidic and imaging technologies
Unmasking the Impacts and Origins of Cell-to-Cell Bioprocessing Diversity at the Single-Cell Level
Single cell analyses have recently unmasked the random character of intracellular reactions, with a particular focus on gene expression. These unexpected discoveries have revolutionized how we view this central dogma of life. Nevertheless, how such intracellular randomness translates to more complex bioprocessing pathways has not been completely understood. In this talk, I will discuss our recent results unmasking that intracellular randomness not only extends past gene expression, but is also heavily involved in multi-cascade reactions during response and biosynthesis. To this end. I will present two bioprocessing examples; the first is lipogenesis for biofuel production [1, 2]; the second is immunomodulation for cancer therapy [3, 4]. Both studies were executed at the single-cell level using microfluidics and bioimaging. Such enabling biotechnologies will also be detailed.
