Walker believes the neurotransmitter dynorphin may contribute to the mood-altering effect.
It works in the brain similarly to the more familiar endorphin, which produces a feeling of well-being commonly referred to as a “runner’s high,” only dynorphin has the opposite effect.
Naltrexone blocks the effects of endorphins, so drinking no longer produces an elevation in mood.
“I am the on the pre-clinical side,” said Walker. “You have to have a good idea, backed up by substantial evidence, before you get to the next step.”